Monday, February 24, 2014

Functionalized magnetonanoparticles in visualization of intracranial tumors on MRI.

Functionalized magnetonanoparticles in visualization of intracranial tumors on MRI.
Mol Imaging Biol. 2013 Jun;15(3):299-306
Authors: Akhtari M, Pope W, Mathern G, Moats R, Frew A, Mandelkern M

PURPOSE: The development of nonradioactive and targeted magnetonanoparticles (MNP) capable of crossing the blood-brain barrier (BBB) and of concentrating in and enhancing the contrast of intracranial tumors on magnetic resonance imaging (MRI).
PROCEDURE: Nonradioactive 2-deoxy-D-glucose (2DG) was covalently attached to magnetonanoparticles composed of iron oxide and dextran and prepared for intravenous (tail) injection in the na├»ve rats and mouse models of glioma. MR images were acquired at 3 and 7 T.
RESULTS: 2DG-MNP increased tumor visibility and improved delineation of tumor margins. Histopathology confirmed that 2DG-MNP crossed the BBB and accumulated within brain parenchyma.
CONCLUSION: Nonradioactive 2DG-MNP can cross an intact BBB on and improve visualization of tumor and tumor margins on MRI.

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