Wednesday, March 12, 2014

The predictive value of treatment response using FDG PET

PURPOSE: what is the prognostic value of FDG PET performed during early chemotherapy in patients with esophageal carcinoma?

METHODS: there were 57 patients with squamous cell carcinoma of the esophagus evaluated. Each patient underwent FDG PET prior to chemotherapy. Patients were classified as showing a complete response or noncomplete response.

RESULTS: SUVmax, SUVmean and Total Lesion Glycolysis decreased significantly between the baseline and followup PET scans.Variables on the baseline, but not followup PET or changes from baseline to followup PET scan were predictive of the response to chemotherapy.

CONCLUSION: parameters derived from baseline PET scan are good predictors of response to chemotherapy. A high tumor volume and total lesion glycolysis were found to be associated with a poor response to chemotherapy at 3 months and 1 year. A high SUVmax was found to be associated with a poor response to chemotherapy at 1 year. FDG PET performed during chemotherapy at week 3 appears to have less clinical relevance although patients with a large tumor volume at that time were found to have a poor clinical outcome.

Eur J Nucl Med Mol Imaging. 2013 Sep;40(9):1345-55